Ahead of the weekend's trip to St Mary's, we look to test your knowledge about history between ourselves and our opponents.
The two sides have met 141 times in all competitions, with the first meeting coming back in 1908 and the most recent fixture being played back in April 2012.
Head-to-head, the Sky Blues come out on top with 49 wins to Southampton's 47 and the other 45 fixtures being played out to a draw.
So, we want to test your knowledge between the two sides and you have six minutes to answer nine questions, can you get all ten?