Ben Stevenson and Max Biamou return in place of Stuart Beavon and Rod McDonald as City look to avoid upset in the Second Round of the FA Cup.
Mark Robins makes just two changes as the side return to their familiar 4-2-3-1 formation with Biamou in attack.
Behind him, Duckens Nazon and Marc McNulty acompany Jordan Shipley to complete the attacking three in midfield.
Stevenson fills the void left by the injured Liam Kelly who remains sidelined with a heel injury, alongisde captain Michael Doyle who makes his 21st FA Cup start for the Sky Blues, 14 years on from his first.
Lee Burge keeps his place in goal with a back four of Jack Grimmer, Jordan Willis, Tom Davies and Ryan Haynes.
Coventry City XI: O'Brien (GK); Grimmer, Willis, McDonald, Haynes; Stevenson, Doyle (C); Nazon, McNulty, Shipley; Ponticelli.
Subs: Burge (GK), Stokes, Dev. Kelly-Evans, Bayliss, Sayoud, Biamou, Beavon.
Boreham Wood XI: G. Smith (GK), K. Smith, Ricketts (C), Wells, Stephens, Shakes, Champion, Murtagh, Andrade, Turgott, Holman
Subs: Bozkurt (GK), Woodards, Benson, Jeffers, Sach, Turley, Balanta.